VENTRICULAR, ATRIAL, AND OUTFLOW TRACT HEART PROGENITORS ARISE FROM SPATIALLY AND MOLECULARLY DISTINCT REGIONS OF THE PRIMITIVE STREAK.

Ventricular, atrial, and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak.

The heart develops from 2 sources of mesoderm progenitors, the first and second heart field (FHF and SHF).Using a single-cell transcriptomic assay combined with genetic lineage tracing and live imaging, we find the FHF and SHF are subdivided into distinct pools of progenitors in gastrulating mouse embryos at earlier stages than previously thought.E

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VCP regulates early tau seed amplification via specific cofactors

Abstract Background Neurodegenerative tauopathies may progress based on seeding by pathological tau assemblies, whereby an aggregate is released from one cell, gains entry to an adjacent or connected cell, and serves as a specific template for its own replication in the cytoplasm.Seeding into the complex cytoplasmic milieu happens within hours, imp

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